The Applied Nutriceuticals research and development team has developed a powerful and biologically efficient post-workout nutrient enhancement product. A precisely proportioned combination of Phosphocreatine and creatine monohydrate (Mono/PCr complex) is the primary element, which plays a vital support role in cellular energy production by regenerating ATP in skeletal muscle and makes it available for explosive exercises 1-5. Another important component of NeoVar, Corosolic Acid is extracted from the Banaba plant, an herb that grows in India, Southeast Asia, and the Philippines. The final component of NeoVar, D-Pinitol, is a cutting-edge compound that has been suggested to support increased nitric oxide production and nutrient sensitivity which are key factors in nutrient transport. The individual effects of these compounds combine synergistically to produce a support a dramatically positive impact on the strength, size, and endurance of skeletal muscle tissue.*
The theory behind the synergism of the Mono/PCr Complex is quite simple: It aims to match the CRfree 40/PCr 60 ratio of the naturally occurring human skeletal intramuscular creatine pool as closely as possible; helping support greater absorption and utilization with minimal waste. The product is blended to maximize PCr levels, while at the same time including monohydrate due to its high molar percentage of creatine as the active ingredient. Human skeletal muscle creatine stores are comprised of approximately 40% in the free creatine form (CRfree), while the remaining 60% is in the phosphorylated form; creatine phosphate (CP). The Mono/PCr complex in NeoVar essentially supports both CRfree levels and phosphocreatine levels in this optimized ratio, which is chemically identical to what is stored in the working muscles 1,3-5. Several animal studies suggest that CRfree has great availability for site phosphorylation for the production of ATP, and further studies are currently underway on the validation of this theory in humans. Similarly, research on phosphate suggests that it has numerous benefits in the athletic realm even without creatine, especially in terms of buffering lactic acid during explosive exercise. Phosphate supplementation has been suggested to promote levels of 2,3-diphosphoglycerate (2,3-DPG), the enzyme that unloads oxygen into muscle. Research suggests that phosphate supplementation may help raise blood levels of 2,3-DPG, and may also encourage the production and use of glycogen for fuel. Therefore, this blend of both CRfree and PCr could allow skeletal muscle to "recognize" and assimilate the creatine in a more refined manner, allowing for a significant degree of uptake enhancement in skeletal muscle tissue 32-38.
A recent trend in creatine supplementation has been the development of exotic esters and alkaline/time-released delivery systems. In developing NeoVar, we researched virtually every creatine derivative currently available before arriving with the final formulation. We analyzed numerous and often conflicting studies regarding the benefits of each and found many of the so-called improvements actually reduced the effectiveness of the products they were used in. Ultimately we elected to avoid this trend, which is proving to be more about company´s efforts to differentiate their products than actual effectiveness.
In developing NeoVar, we sought to use the molecules used in numerous human studies to replicate the exact physiological ratios found in the intramuscular creatine pool in human skeletal muscle so the body may recognize and utilize it readily.
Creatine provides a variety of anabolic effects on skeletal muscle, supporting increased lean body mass while being a source of ATP (adenosine tri-phosphate, a source of cellular energy that aids in muscle contraction).* Increased CP stores in the muscle have been suggested to allow for greater intracellular water retention. Greater intracellular water retention from increased CP raises osmotic pressure within the cell, which may allow for heightened protein synthesis and nitrogen retention. Heightened protein synthesis and nitrogen retention may support an anabolic environment that's very favorable for intense muscular growth 2-4. Creatine uptake into the muscle may also be influenced by glucose, as the correct manipulation of these entities can allow for much larger amounts of creatine to be stored within the muscle cells. This is the main goal of NeoVar- to allow for the greatest amounts of creatine to be stored in working muscle through the manipulation of different nutrients 1-6.
As we know, creatine supplementation may help support increased intramuscular creatine stores, but to greatly varying extents. Many manufacturers suggest an initial loading dose to accelerate creatine saturation within the cell; however this method commonly produces uncomfortable abdominal cramps and bloating. In the early 90´s researchers suggested that ingesting creatine w/ high glycemic carbohydrates such as dextrose dramatically raised skeletal muscle concentrations of creatine beyond regular oral supplementation alone. More recent research has suggested that taking creatine with glucose (25-100 g), or with combinations of glucose and protein (around 30-40 grams of each macronutrient) may allow for larger amounts of creatine storage due to the increased insulin secreted in response to the carbohydrate intake 1,5,6. While moderately effective, these techniques fall short because some of the ingested creatine may not absorbed. The objective when developing NeoVar was to discover other compounds that can further support a great uptake of intramuscular creatine.
Bioperine
Bioperine (piperine 95%) is a revolutionary compound that may help support the increased uptake of certain supplements and nutrients. Bioperine is hugely important in the formulation of NeoVar as an effective post-workout recovery and growth enhancement support product, because it may help the stomach and small intestine absorb greater proportions of the other active ingredients in NeoVar.* Bioperine is also suggested to help decrease the breakdown of many nutrients by the liver, which may allow for greater amounts of active ingredients to stay in the bloodstream for a longer period of time; making them more available for uptake by hard-working muscles.* 40-42.
D-Pinitol
The cutting-edge compound D-Pinitol is also an integral component of NeoVar. D-pinitol stimulated glucose uptake to an extent similar to that of insulin 26-30. In the presence of a low insulin concentration a synergistic effect was observed between pinitol and insulin. In addition, d-pinitol may support increased glycogen synthesis in the muscle cells. However, the main reason D-Pinitol truly shines in this formulation is that it has been suggested to enhance creatine storage in human subjects. Creatine loading alone has been reported to increase muscle creatine and phosphocreatine stores by 5 to 30% 1-4.*
Essentially, NeoVar combines the benefits of some of the most biologically available creatines with compounds that channel them into hard-working muscle cells quickly and efficiently.* Precisely dosed, and in convenient capsules, few other product delivers can the goods like NeoVar - at any price.
Supplement Facts :
Serving Size : 1Capsule
Amount Per Capsule : 750mg
PCr-Mono Matrix™ (Proprietary Blend) 646mg 
Phosphocreatine  *
Creatine Monohydrate  *
Glucovar / Adenylate Cyclase Sensitization Complex (Proprietary Blend) 104mg 
Banaba Extract (Lagerstroemia Speciosa 1% Corosolic Acid)  *
Gymnema Sylvestre (75% Extract0*  *
D-Pinitol  *
Bioperine® (95% - 98% Piperine)* Registered Trademark Of Sabinsa Corp. And Holds Patent # 5,536,506  *
* Daily Value not established
Inactive Ingredients
Gelatin, Candurin® Silver Fine, FD&C Red #3, FD&C Yellow #5, FD&C Blue #1
Recommended Use For Applied Nutriceuticals NeoVar:
Take immediately post-workout with carbohydrates, preferably sugars. Take second dose with any other meal throughout the day containing carbohydrates.
Suggested Dosage with Carbohydrates:
Up to 150 Lbs : 2 Capsules ( 4 Daily)
150-250Lbs : 3 Capsules ( 6 daily)
250Lbs and more : 4 Capsules (8 Daily)
Warnings:
This product is only intended to be consumed by healthy adults 18 years of age or older. Do not use if you are pregnant or nursing. Before using product, seek advice from a physician if you are unaware of your current health condition or have any pre-existing medical condition including but not limited kidney disease or if you are taking any prescription or over the counter medication. Do not use if you are pregnant, nursing, prone to dehydration or exposed to excessive heat. Discontinue use and consult your health care professional if you experience any adverse reaction to this product. Before beginning any weight loss program, consult your health care provider. Keep Out Of Reach Of Children.
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Content : 240 Capsules